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Medications for Parkinson's

There is no cure at the moment for Parkinson's disease, but there are several medications available that can help manage the symptoms. There are several medications commonly used to treat Parkinson's disease. Here is an overview of some of the main classes of medications prescribed for Parkinson's:

  1. Levodopa (L-dopa): Levodopa is the most effective medication for managing the motor symptoms of Parkinson's disease. It is converted into dopamine in the brain to replenish the dopamine levels that are reduced in Parkinson's. Commonly prescribed levodopa formulations include Sinemet (levodopa/carbidopa) and Madopar (levodopa/benserazide).

  2. Dopamine agonists: These medications directly stimulate dopamine receptors in the brain. They can be used alone or in combination with levodopa. Examples of dopamine agonists include Pramipexole (Mirapex), Ropinirole (Requip), and Rotigotine (Neupro).

  3. MAO-B inhibitors: Monoamine oxidase-B (MAO-B) inhibitors block the enzyme that breaks down dopamine in the brain, thereby increasing dopamine levels. These medications are often used as early-stage treatment or in combination with other Parkinson's medications. Examples include Rasagiline (Azilect) and Selegiline (Eldepryl, Zelapar).

  4. Catechol-O-methyltransferase (COMT) inhibitors: COMT inhibitors prevent the breakdown of levodopa in the body, prolonging its effects and reducing fluctuations in motor symptoms. Entacapone (Comtan) and Tolcapone (Tasmar) are examples of COMT inhibitors.

  5. Anticholinergics: These medications help balance the levels of acetylcholine, a neurotransmitter that becomes imbalanced in Parkinson's disease. They can help control tremors and rigidity. Examples include Trihexyphenidyl (Artane) and Benztropine (Cogentin).

  6. Amantadine: Originally developed as an antiviral medication, amantadine can also provide relief for Parkinson's symptoms, especially tremors. It may be used alone in early-stage Parkinson's or in combination with other medications.


It's important to note that medication choices and dosages are highly individualized based on the specific needs and response of each person with Parkinson's disease. A neurologist or movement disorder specialist is best equipped to evaluate and prescribe the appropriate medications for an individual's unique condition. Regular follow-up visits are necessary to monitor the effectiveness of medications and make any necessary adjustments.


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